超级病毒“金美拉”和抗生素在运送途中，被恐怖组织头目Sean Ambrose（ Dougray Scott 饰）盗走，Ethan Hunt（Tom Cruise 饰）率领他的IMF小组接受中情局的任务，找回病毒。
这次，Ethan Hunt找到了女飞贼Nyah Nordoff-Hall（Thandie Newton 饰）搭档，后者是Sean Ambrose的前女友。Ethan Hunt在获取Nyah信任的同时，二人也暗生情愫。
但是，为了完成任务，Ethan Hunt不得不安排Nyah回到Sean Ambrose身边卧底。
Nyah终于打探出病毒所在的药厂，接获情报的Ethan Hunt前往药厂准备销毁病毒；另一边，Sean Ambrose已经察觉出了Nyah回到自己身边的真正目的，组织人马在药厂等待Ethan Hunt自投罗网。
激烈的搏斗中，Nyah为了帮助Ethan Hunt完成任务，将病毒注入了自己体内，只有在20个小时之内将抗生素注入Nyah体内，才能挽救她的性命，Ethan Hunt又将面临不可能的任务。(豆瓣)

Hans Zimmer's music for Mission Impossible 2 blends rock, electronica, world, and symphonic elements into an uneven score that ranges from successful eclecticism to bombastic predictability. Some of Zimmer's most interesting and effective moments are his quietest: subtle, sensual, flamenco-inspired pieces like "Seville" and "Nyah" (which features guitarist Heitor Pereira) are more compelling than the over-the-top samples, beats, and techno explosions on tracks such as "Mano a Mano" and "Bio-Techno." Zap Mama's version of the African folk-pop classic "Iko Iko" and Zimmer's techno-rock update of Lalo Schifrin's "Mission: Impossible Theme" provide some of the other highlights from this score. Like the film itself, Mission Impossible 2 doesn't always find the right balance for its explosive and contemplative moments, but will probably please Zimmer fans as well as fans of the movie.