Wave of Mutilation: Best of Pixies is a compilation album by Pixies. It was released on May 3, 2004 in the United Kingdom and the following day in the United States alongside a companion DVD featuring a live show, promotional videos and two documentaries. Early batches of the record feature a fault on the track "Hey", where Black Francis' opening shout of "Hey" is missing.

This album replaces 1997's compilation Death to the Pixies in 4AD's catalog, which previously served as the label's "greatest hits" collection for the Pixies.